Collective cell migration without proliferation: density determines cell velocity and wave velocity
نویسندگان
چکیده
منابع مشابه
Waves in cell monolayer without proliferation: density determines cell velocity and wave celerity
Collective cell migration contributes to morphogenesis, wound healing or tumor metastasis. Culturing epithelial monolayers on a substrate is an in vitro configuration suitable to quantitatively characterize such tissue migration by measuring cell velocity, density and cell-substrate interaction force. Inhibiting cell division, we limit cell density increase and favor steady cell migration, whil...
متن کاملWave-equation Migration Velocity Analysis
In this report, we introduce a new wave-equation method of migration velocity analysis (MVA). The method is based on the linear relation that can be established between a perturbation in the migrated image and the generating perturbation in the slowness function. Our method consists of two steps: we first improve the focusing of the migrated image and then iteratively update the velocity model ...
متن کاملBowhead: Bayesian modelling of cell velocity during concerted cell migration
Cell migration is a central biological process that requires fine coordination of molecular events in time and space. A deregulation of the migratory phenotype is also associated with pathological conditions including cancer where cell motility has a causal role in tumor spreading and metastasis formation. Thus cell migration is of critical and strategic importance across the complex disease sp...
متن کاملBroad-tailed force distributions and velocity ordering in a heterogeneous membrane model for collective cell migration
Correlated velocity patterns and associated large length-scale transmission of traction forces have been observed in collective live cell migration as a response to a “wound”. We argue that a simple physical model of a force-driven heterogeneous elastic membrane sliding over a viscous substrate can qualitatively explain a few experimentally observed facts: (i) the growth of velocity ordering wh...
متن کاملWave - equation migration velocity analysis . I . Theory
We present a migration velocity analysis (MVA) method based on wavefield extrapolation. Similarly to conventional MVA, our method aims at iteratively improving the quality of the migrated image, as measured by the flatness of angle-domain commonimage gathers (ADCIGs) over the aperture-angle axis. However, instead of inverting the depth errors measured in ADCIGs using ray-based tomography, we in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Royal Society Open Science
سال: 2018
ISSN: 2054-5703
DOI: 10.1098/rsos.172421